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Ÿ Biomolecular Science Course

Biomolecular Science Course, International Graduate Course, is based on the Graduate School of Bioscience and Biotechnology, which consists of five departments, i.e., Department of Life Science, Department of Biological Science, Department of Biological Information, Department of Bioengineering, and Department of Biomolecular Engineering. Each student of the Biomolecular Science Course belongs to one of these departments and studies according to the curriculum of corresponding department.  As listed below, many classes are given in English, and 10 of these indicated as gCh in the remarks column of the list are common to all five Departments.

Classes in this list are given in English.

Class Name

Credit

Lecturer(s)

Semester

Remarks

Advanced Bioorganic Chemistry

2-0-0

Okahata, et al.

Autumn

E, C

Advanced Molecular Biology

2-0-0

Handa, et al.

Autumn

E, C

Bioengineering Now

2-0-0

Unno, et al.

Autumn

E, C

Advanced Life Science Frontiers

2-0-0

Tamanoi

Spring

O, C

Synthesis of Bioactive Substances

2-0-0

Yuasa

Autumn

E

Applied Microbiology

2-0-0

Ishikawa

Spring

E

Biomolecular Systems

2-0-0

Ikai

Spring

E

Advanced Cell Biochemistry

2-0-0

Komada

Spring

E

Bioscience and Biotechnology International Communication I

2-0-0

 

Spring

O, C

Advanced Course of Bioscience Communication

2-0-0

Arimura

Autumn

Advanced Biophysical Chemistry

2-0-0

Tanaka, et al,

Autumn

O, C

Advanced Biochemistry

2-0-0

Hirose, et al.

Autumn

O, C

Advanced Biology

2-0-0

Takamiya, et al.

Autumn

Advanced Biotechnology Frontiers

2-0-0

Spring

Advanced Course of Biological Recognition and Signaling II

2-0-0

Saitoh

Autumn

O

Asymmetric Synthesis

2-0-0

Kobayashi

Autumn

O

Biomolecular Systems

2-0-0

Arisaka

Spring

"E" or "O" in the remarks column shows that those classes are open in even or odd year, respectively, The classes without such symbols are open every year. "C" in the remarks column indicates the class common to all departments of Biomolecular Science Course.


<2004 Autumn Semester>

Advanced Bioorganic Chemistry (2-0-0)

2nd period of even year     

Prof. Yoshio Okahata, Associate Prof. Toshiaki Mori, and Associate Prof. Hisakazu Mihara

(Aim)

Bioorganic chemistry related to "molecular recognition" of small organic molecules, proteins, peptides, nucleic acids, and saccharides for the study of bioscience and biotechnology is expounded.

(Schedule)

 1. Introduction, what are molecular recognitions?

 2. Molecular recognition in small organic molecules

 3. Molecular recognition of nucleic acids (1)

 4. Molecular recognition of nucleic acids (2)

 5. Molecular recognition of enzymes (1)

 6. Molecular recognition of enzymes (2)

 7. Molecular recognition of saccharides (1)

 8. Molecular recognition of saccharides (2)

 9. Molecular recognition of peptides (1)

10. Molecular recognition of peptides (2)

11 Molecular recognition of proteins (1)

12 Molecular recognition of proteins (2)

(How to Grade)

Attendance and reports

(Text, etc.)

Lecturers will prepare prints, and a class will be held as a round table style in small members.


Advanced Molecular Biology (2-0-0) Even year

Prof. Hiroshi Handa

(Aim)

There are several approaches to investigate biological reactions in organisms.  One promising approach among them is to use small chemical compounds which affect the cell status and induce specific cell responses after addition of the compounds.  This approach has recently been classified as Chemical Biology, and is gradually developing all over the world. In this lecture, I will talk about topics in the field of Chemical Biology and discuss how to proceed with basic and advanced researches.     

(Schedule)

Will be announced at the first lecture

(How to grade)

Will be announced at the first lecture


Bioengineering Now (2-0-0) Even year

Prof. Hajime UNNO, Prof. Eiry KOBATAKE, Takao KATAOKA

(Aim)

Most advanced research status of bioengineering is to be learned, where bio-functions derived from biological elements such as viruses/phages, enzymes, microbes, plant/animal cells are applied to the construction of innovative systems for producing materials and/or energy, and contributing environmental technology.

(Schedule)

1. Environmental bioengineering

1-1. Microbial functions for material cycle in ecosystem

1-2. Functional interaction in microbial consortium: Wastewater treatment system

1-3. Biochemical factors for the eutrophication and their engineering countermeasures 

1-4. Bioengineering approach to environmental compatibility: Production and/or degradation of biodegradable plastics

2. Genetic engineering for bio-sensing systems

2-1. Design of chimera proteins

2-2. Protein molecular assembling

2-3. Analysis of DNA-protein interaction by AFM

2-4. Construction of cellular bio-sensing System

3. Cell technology for regulation of biological functions

3-1. Biological active compounds produced by microorganisms

3-2. Bio-probes that regulate cellular functions

3-3. Cell technology for animal cells

3-4. Animal cell technology and its application


Synthesis of Bioactive Substances (2-0-0) Even year

Associate Prof. Hideya YUASA

(Aim)

Organic synthesis is one of the most powerful tools to create drugs for diseases, such as cancer, diabetes, flu, and etc. Thus the knowledge and skills of organic synthesis are prerequisite for the research in pharmaceutical industry. The aim of this class is to have you understand the logics and mechanisms underlying the design and synthesis of bioactive molecules. To make the class less bored, each lecture will deal with the synthesis of a few compounds, with which the basic principles behind the constituent reactions will be uncovered. Therefore, you do not have to attend all of the classes. The first half of this class will be based on the text book, gTop Drugs: Top Synthetic Routesh (John Saunders, Oxford University Press: Oxford, 2000). Our own research results are discussed in the latter half.

(Schedule)

1. Inhibitors of angiotensin converting enzyme

2. Blockade of angiotensin-II receptors

3. Calcium channel blockers

4. Antagonists of histamine receptors

5. Proton pump inhibitors

6. Modulation of central serotonin

7. Ligands for benzodiazepine receptor

8. Blockers of the H1 recptor

9. Inhibitors of HIV reverse transcriptase

10. Anti-bacterial DNA gyrase inhibitors

11. Glycosidase inhibitors against diabetes

12. Carbohydrate-based future drugs

13. Principles of mimics and mimetics

14. Dynamic molecules for future drugs

15. Peptide synthesis (optional)

(How to grade)

Attendance and report


<2005 Autumn Semester>

Advanced Course of Biological Recognition and Signaling II (2-0-0) Odd year

Assoc. Prof. Yuji SAITO

(Aim)

Students will learn the up-to-date knowledge and the ways to carry out research about biological signal transduction. This object could be attained not only from the lectures given by the instructor but also by actively participating in a series of presentations given by fellow students.

(Schedule)

1. Give basic and general understanding about Biological Signal Transduction. (2 weeks)

Explain various receptors and molecules involved in different biological signal transduction pathways, and cross-talks among them.

2. Discuss about various oncogenes and tumor suppressors with regard to apoptosis, differentiation

and cancer, based on topics published in recent literatures. (2 weeks)

3. Students are expected to make a bit formal presentations about a series of subjects chosen from current literature. Students will learn from this experience how to write and read papers as well as how to give a talk in conferences. (8 weeks)

(How to grade)

Students are expected to attend lectures as often as possible, and actively participate in the discussion about the topics presented by fellow students.


Asymmetric Synthesis (2-0-0) Odd year

Associate Prof. Yuichi KOBAYASHI

(Aim)

Asymmetric reaction is one of the most powerful methods to prepare chiral compounds.   Presented herein is some of the efficient asymmetric reactions by which high enantiomeric excess of the products is attained.   The principle and the mechanism for the creation of chiral centers in the molecules are also discussed. 

(Schedule)

 1. Fundamental Aspects of Asymmetric Synthesis

 2. Preparation of Chiral Compounds by means of Optical Resolution, Asymmetric Synthesis, Chiral

Pool Method, Reactions using Enzymes

 3. Diastereoselection and Enantioselection

 4. Selectivity in the Enolate Formation and the Asymmetric Alkylation

 5. Asymmetric Aldol Condensations: Part 1

 6. Asymmetric Aldol Condensations: Part 2

 7. Catalytic Asymmetric Reactions: Part 1:

Hydrogenation, Isomerization, Allylic Substitution

 8. Catalytic Asymmetric Reactions: Part 2:

Cyclopropanation, Diels-Alder Reaction

 9. Asymmetric Epoxidation

10. Transformations of Epoxides

11. Asymmetric Dihydroxylation

12. Asymmetric Reactions of Compounds with Symmetry Elements

13. Chiral Pool Method

14. Asymmetric Synthesis of Biologically Active Compounds

15. Summary

 

(How to grade)

Attendance and report


List of Normal-course Lectures (Given in Japanese, but international graduate course students can also attend

and acquire credits)


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