Dualmodal bone tracer from dextran polysaccharide template

Multimodal bioimaging tracer technology a promising not only for the analysis of living cells, but also for diagnosis because no single modality is perfect and sufficient to obtain all the necessary information for a particular question.

However, the synthesis of multimodal imaging tracers requires the repeatable and suitable attachment of multiple functional molecules without any unexpected physical-chemical interference between the incorporated molecules.

Now, Hiroshi Tanaka and colleagues at Tokyo Insitute of Technology, Kyoto University and National Institute of Radiological Sciences report on the synthesis of a dualmodal bone tracer from dextran polysaccharide template and bioimaging of regenerated bone model by magnetic resonance and optical imaging.

Dualmodal bone tracers were preared from dextran polysaccharide-based templates containing terminal acetylens and amino groups via coupling with carboxylic acids bearing sensing devices and azide derivatives bearing a biphoshonate as binding ligands to the bone.

The dextran-based bone tracers visualized regenerated bone in BMP-2 installed hydrogel in mice by magnetic resonance and optical imaging without unfavarable side-effects.

Dextran polysaccharides possessing multiple terminal acetylenes and amino groups show potential as templates for the synthtesis of multimodal imaging tracers.

Reference

Authors:	Hiroshi Tanaka1, Sho Yamaguchi1, Jun-ichiro Jo2, Ichio Aoki2, Yasuhiko Tabata3 and Takashi Takahashi1
Title of original paper:	Synthesis of a Dextran-Based Bone Tracer for in vivo Magnetic Resonance and Optical Imagings by Two Orthogonal Coupling Reactions
Journal, volume, pages and year:	RSC Advance 4, 7561 (2014).
Digital Object Identifier (DOI):	10.1039/C3RA46142D
Affiliations:	1Department of Applied Chemistry, Tokyo Institute of Technology, 2Molecular Imaging Center, National Institute of Radiological Sciences, and 3Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University

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