Tokyo Tech News

Dualmodal bone tracer from dextran polysaccharide template


February 17, 2015

Multimodal bioimaging tracer technology a promising not only for the analysis of living cells, but also for diagnosis because no single modality is perfect and sufficient to obtain all the necessary information for a particular question.

However, the synthesis of multimodal imaging tracers requires the repeatable and suitable attachment of multiple functional molecules without any unexpected physical-chemical interference between the incorporated molecules.

Now, Hiroshi Tanaka and colleagues at Tokyo Insitute of Technology, Kyoto University and National Institute of Radiological Sciences report on the synthesis of a dualmodal bone tracer from dextran polysaccharide template and bioimaging of regenerated bone model by magnetic resonance and optical imaging.

Dualmodal bone tracers were preared from dextran polysaccharide-based templates containing terminal acetylens and amino groups via coupling with carboxylic acids bearing sensing devices and azide derivatives bearing a biphoshonate as binding ligands to the bone.

The dextran-based bone tracers visualized regenerated bone in BMP-2 installed hydrogel in mice by magnetic resonance and optical imaging without unfavarable side-effects.

Dextran polysaccharides possessing multiple terminal acetylenes and amino groups show potential as templates for the synthtesis of multimodal imaging tracers.

Bioimaging of Bone Regenerate Process.
Bioimaging of Bone Regenerate Process.


Hiroshi Tanaka1, Sho Yamaguchi1, Jun-ichiro Jo2, Ichio Aoki2, Yasuhiko Tabata3 and Takashi Takahashi1
Title of original paper:
Synthesis of a Dextran-Based Bone Tracer for in vivo Magnetic Resonance and Optical Imagings by Two Orthogonal Coupling Reactions
Journal, volume, pages and year:
RSC Advance 4, 7561 (2014).
Digital Object Identifier (DOI):
1Department of Applied Chemistry, Tokyo Institute of Technology, 2Molecular Imaging Center, National Institute of Radiological Sciences, and 3Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University

Further information
Associate Professor Hiroshi Tanaka
Department of Applied Chemistry
Graduate School of Science and Engineering
TEL +81-3-5734-2471