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A materials science approach to combating coronavirus

New cerium molybdate material could be a game-changer in managing SARS-CoV-2

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Published: March 4, 2021

Researchers at Tokyo Institute of Technology working in collaboration with colleagues at the Kanagawa Institute of Industrial Science and Technology and Nara Medical University in Japan have succeeded in preparing a material called cerium molybdate (γ-Ce2Mo3O13 or CMO), which exhibits high antiviral activity against coronavirus.

The ongoing coronavirus pandemic has highlighted the urgency not only of vaccine development and rollout but also of developing innovative materials and technologies with antiviral properties that could play a vital role in helping to contain the spread of the virus.

Conventional inorganic antimicrobial materials are often prepared with metals such as copper or photocatalysts such as titanium dioxide. However, metal-based materials can be prone to corrosion, and the effects of photocatalysts are usually limited under dark conditions.

Now, a research team led by Akira Nakajima of Tokyo Institute of Technology's Department of Materials Science and Engineering proposes a new type of an antiviral material that can overcome these drawbacks. The team successfully combined a relatively low-cost rare earth element cerium (Ce) with molybdenum (Mo), which is well known for its antibacterial effects, to prepare two types of cerium molybdate (Ce2Mo3O12 and γ-Ce2Mo3O13) in powder form.

Both powders exhibited antiviral activity against bacteriophage Φ6[1]. Notably, γ-Ce2Mo3O13 also exhibited high antiviral activity against SARS-CoV-2, the virus that causes COVID-19.

Figure 1.  (a) Antiviral activity of prepared powders against coronavirus and photographs showing the change in plaque number of coronavirus after four hours: (b) control and (c) with CMO.

Figure 1. (a) Antiviral activity of prepared powders against coronavirus and photographs showing the change in plaque number of coronavirus after four hours: (b) control and (c) with CMO.

After four hours, the CMO powder reduced the level of coronavirus by four orders of magnitude (to less than 1/10,000 of the original level). The antiviral activity of CMO against coronavirus was found to exceed that of both LCMO and MoO3.

The researchers infer that an effective combination of cerium with the molybdate ion as well as the specific surface area[2] are key factors contributing to the observed antiviral activity.

The study builds on earlier work led by Nakajima which demonstrated the antiviral activity of a material named LMO (La2Mo2O9), composed of lanthanum (La) oxide and molybdenum oxide. LMO’s activity, however, was found to be better against non-envelope-type (bacteriophage Qβ) than against envelope-type (bacteriophage Φ6) viruses. Subsequent tests showed that incorporating cerium into the material to make La1.8Ce0.2Mo2O9 (LCMO) improved antiviral activity against bacteriophage Φ6. It was this remarkable finding that spurred further investigations into cerium molybdates (CMO) as promising materials with high antiviral activity against envelope-type viruses such as influenza and SARS-CoV-2.

To obtain the desired CMO powder samples with an almost single-crystal phase, the team conducted many trial experiments before successfully preparing Ce2Mo3O12 using the polymerizable complex method and γ-Ce2Mo3O13 through hydrothermal processing[3].

If standardized and mass-produced, CMO could be used in a wide range of materials such as resins, paper, thin films and paints. This would open up the possibility of using CMO coatings for high-contact surfaces such as door handles, straps inside vehicles, elevator buttons and escalator belts as well as walls, tiles and windows. Nakajima envisions that materials incorporating CMO could also be used in everyday items such as smartphones and clothing. He notes that applications for eye and face ware such as glasses and masks may take a little longer time to develop, but be on the horizon.

Figure 2. Scanning electron microscope image of CMO powder

Figure 2. Scanning electron microscope image of CMO powder

Technical terms

[1] bacteriophage Φ6 : A member of the virus family Cystoviridae that has the rare distinction of having a lipid envelope. It is thus considered a useful surrogate for enveloped viruses and is often used as a model in studies investigating antiviral activity.

[2] specific surface area : Here referring to the total available surface area for adsorption of the virus.

[3] hydrothermal processing : A method harnessing the chemistry of hot water under pressure that enables effective dissolution, which can yield high-quality inorganic products.

Reference

Authors :
Takuro Ito1, Kayano Sunada2, Takeshi Nagai2, Hitoshi Ishiguro2, Ryuichi Nakano3, Yuki Suzuki3, Akiyo Nakano3, Hisakazu Yano3, Toshihiro Isobe1, Sachiko Matsushita1, Akira Nakajima1,*
Title of original paper :
Preparation of cerium molybdates and their antiviral activity against bacteriophage Φ6 and SARS-CoV-2.
Journal :
Materials Letters (2021)
DOI :
Affiliations :

1 Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology

2 Antibacterial and Antiviral Research Group, Kanagawa Institute of Industrial Science and Technology

3 Department of Microbiology and Infectious Diseases, Nara Medical University

School of Materials and Chemical Technology

School of Materials and Chemical Technology
—Encompassing the Disciplines of Science—

Information on School of Materials and Chemical Technology inaugurated in April 2016

School of Materials and Chemical Technology

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Further Information

Professor Akira Nakajima

School of Materials and Chemical Technology
Tokyo Institute of Technology

Email nakajima.a.aa@m.titech.ac.jp
Tel +81-3-5734-2524

Contact

Public Relations Group, Tokyo Institute of Technology

Email media@jim.titech.ac.jp
Tel +81-3-5734-2975

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