Selected publications

2017

• Recycling of iron via autophagy is critical for the transition from glycolytic to respiratory growth Horie T, Kawamata T, Matsunami M, Ohsumi Y. J. Biol. Chem, 10.1074/jbc.M116.762963, [Faculty of 1000], (2017)
• Zinc starvation induces autophagy in yeast Kawamata T, Horie T, Matsunami M, Sasaki M, and Ohsumi Y. J. Biol. Chem, 10.1074/jbc.M116.762948, [editor’s pick up], (2017)

2016

• The intrinsically disordered protein Atg13 mediates supramolecular assembly of autophagy initiation complexes. Hayashi Yamamoto, Yuko Fujioka, Sho W. Suzuki, Daisuke Noshiro, Hironori Suzuki, Chika Kondo-Kakuta, Yayoi Kimura, Hisashi Hirano, Toshio Ando, Nobuo N. Noda & Yoshinori Ohsumi Dev. Cell., 10.1016/j.devcel.2016.06.015

2015

• The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy Yamamoto H, Shima T, Yamaguchi M, Mochizuki Y, Hoshida H, Kakuta S, Kondo-Kakuta C, Noda NN, Inagaki F, Itoh T, Akada R, Ohsumi Y J. Biol. Chem., 10.1074/jbc.M115.684233 (2015)
• Phospholipid methylation controls Atg32‐mediated mitophagy and Atg8 recycling Sakakibara K. Eiyama A. Suzuki SW. Sakoh‐Nakatogawa M. Okumura N. Tani M. Hashimoto A. Nagumo S. Kondo‐Okamoto N. Kondo‐Kakuta C. Asai E. Kirisako H. Nakatogawa H. Kuge O. Takao T. Ohsumi Y. Okamoto K. EMBO J., DOI 10.15252/embj.201591440.
• The yeast chromatin remodeler Rsc1-RSC complex is required for transcriptional activation of autophagy-related genes and inhibition of the TORC1 pathway in response to nitrogen starvation. Fei-Fei Yu. Imamura Y. Ueno M. Suzuki SW. Ohsumi Y. Yukawa M. Tsuchiya E. BBRC., 2015.07.114
• Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui , Ueda H, Akazawa Y, Nakayama H, Taneike M, MisakaT, Omiya S, Ajay Shah, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, OtsuK Nat. Commun., 2015, 6, 7527.
• Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Mochida K, Oikawa Y, Kimura Y, Kirisako H, Hirano H, Ohsumi Y,　Nakatogawa H Nature., 2015, 522, 359-362
• Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation. Suzuki SW, Yamamoto H, Oikawa Y, Kondo-Kakuta C, Kimura Y, Hirano H, Ohsumi Y, Proc. Natl. Acad. Sci. USA., 2015.112.3350-3355.
• Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes. Sakoh-Nakatogawa M, Kirisako H, Nakatogawa H, Ohsumi Y FEBS Lett., 2015, 589, Issue 6, 744-749.
• Bulk RNA degradation by nitrogen starvation-induced autophagy in yeast. Huang H, Kawamata T, Horie T, Tsugawa H, Nakayama Y, Ohsumi Y, Fukusaki E. EMBO J., 2015, 34, 154-168.

2014

• Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions. Mochida K, Ohsumi Y, Nakatogawa H. FEBS Lett., 2014, 588, 3862-3869.
• Hrr25 triggers selective autophagy?related pathways by phosphorylating receptor proteins. Tanaka C, Tan LJ, Mochida K, Kirisako H, Koizumi M, Asai E, Sakoh-Nakatogawa M, Ohsumi Y, Nakatogawa H. J. Cell Biol., 2014, 207, 91-105.
• Structural basis of starvation-induced assembly of the autophagy initiation complex. Fujioka Y, Suzuki SW, Yamamoto H, Kondo-Kakuta C, Kimura Y, Hirano H, Akada R, Inagaki F, Ohsumi Y, Noda NN. Nat. Struct. Mol. Biol., 2014, 21, 513-521.
• Proteomic profiling of autophagosome cargo in Saccharomyces cerevisiae. Suzuki K, Nakamura S, Morimoto M, Fujii K, Noda NN, Inagaki F, Ohsumi Y. PLoS One, 2014, 9, e91651.
• Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries. Cheng J, Fujita A, Yamamoto H, Tatematsu T, Kakuta S, Obara K, Ohsumi Y, Fujimoto T. Nat. Commun., 2014, 5, 3207.
• Organ-specific quality control of plant peroxisomes is mediated by autophagy. Yoshimoto K, Shibata M, Kondo M, Oikawa K, Sato M, Toyooka K, Shirasu K, Nishimura M, Ohsumi Y. J. Cell Sci., 2014, 127, 1161-1168.

• Autophagy: close contact keeps out the uninvited. Nakatogawa H, Ohsumi Y. Curr. Biol., 2014, 24, R560-562.
• Plant autophagy is responsible for peroxisomal transition and plays an important role in the maintenance of peroxisomal quality. Shibata M, Oikawa K, Yoshimoto K, Goto-Yamada S, Mano S, Yamada K, Kondo M, Hayashi M, Sakamoto W, Ohsumi Y, Nishimura M. Autophagy, 2014, 10, 936-937.
• Different phosphatidylinositol 3-phosphate asymmetries in yeast and mammalian autophagosomes revealed by a new electron microscopy technique. Fujimoto T, Yamamoto H, Ohsumi Y. Autophagy, 2014, 10, 933-935.
• Historical landmarks of autophagy research. Ohsumi Y. Cell Res., 2014, 24, 9-23.

2013

• Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis. Shibata M, Oikawa K, Yoshimoto K, Kondo M, Mano S, Yamada K, Hayashi M, Sakamoto W, Ohsumi Y, Nishimura M. Plant Cell, 2013, 25, 4967-4983.
• Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. Araki Y, Ku WC, Akioka M, May AI, Hayashi Y, Arisaka F, Ishihama Y, Ohsumi Y. J. Cell Biol., 2013, 203, 299-313.
• Two-Colored Fluorescence Correlation Spectroscopy Screening for LC3-P62 Interaction Inhibitors. Tsuganezawa K, Shinohara Y, Ogawa N, Tsuboi S, Okada N, Mori M, Yokoyama S, Noda NN, Inagaki F, Ohsumi Y, Tanaka A. J. Biomol. Screen., 2013, 18, 1103-1109.
• Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae. Suzuki K, Akioka M, Kondo-Kakuta C, Yamamoto H, Ohsumi Y. J. Cell Sci., 2013, 126, 2534-2544.
• Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site. Sakoh-Nakatogawa M, Matoba K, Asai E, Kirisako H, Ishii J, Noda NN, Inagaki F, Nakatogawa H, Ohsumi Y. Nat. Struct. Mol. Biol., 2013, 20, 433-439.
• Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation. Noda NN, Fujioka Y, Hanada T, Ohsumi Y, Inagaki F. EMBO rep., 2013, 14, 206-211.

2012

• Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7. Yamaguchi M, Matoba K, Sawada R, Fujioka Y, Nakatogawa H, Yamamoto H, Kobashigawa Y, Hoshida H, Akada R, Ohsumi Y, Noda NN, Inagaki F. Nat. Struct. Mol. Biol., 2012, 19, 1250-1256.
• Atg9 vesicles recruit vesicle-tethering proteins, Trs85 and Ypt1, to the autophagosome formation site. Kakuta S, Yamamoto H, Negishi L, Kondo-Kakuta C, Hayashi N, Ohsumi Y. J. Biol. Chem., 2012, 287, 44261-44269.
• Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18. Watanabe Y, Kobayashi T, Yamamoto H, Hoshida H, Akada R, Inagaki F, Ohsumi Y, Noda NN. J. Biol. Chem., 2012, 287, 31681-31690.
• The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation. Nakatogawa H, Ohbayashi S, Sakoh-Nakatogawa M, Kakuta S, Suzuki SW, Kirisako H, Kondo-Kakuta C, Noda NN, Yamamoto H, Ohsumi Y. J. Biol. Chem., 2012, 287, 28503-28507.
• Atg9 vesicles are an important membrane source during early steps of autophagosome formation. Yamamoto H, Kakuta S, Watanabe TM, Kitamura A, Sekito T, Kondo-Kakuta C, Ichikawa R, Kinjo M, Ohsumi Y. J. Cell Biol., 2012, 198, 219-233.
• Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2. Kobayashi T, Suzuki K, Ohsumi Y. FEBS Lett., 2012, 586, 2473-2478.
• Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate. Yamaguchi M, Noda NN, Yamamoto H, Shima T, Kumeta H, Kobashigawa Y, Akada R, Ohsumi Y, Inagaki F. Structure, 2012, 20, 1244-1254.
• Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. Noda NN, Kobayashi T, Adachi W, Fujioka Y, Ohsumi Y, Inagaki F. J. Biol. Chem., 2012, 287, 16256-16266.
• Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy. Kondo-Okamoto N, Noda NN, Suzuki SW, Nakatogawa H, Takahashi I, Matsunami M, Hashimoto A, Inagaki F, Ohsumi Y, Okamoto K. J. Biol. Chem., 2012, 287,10631-10638.
• Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis. Nakatogawa H, Ishii J, Asai E, Ohsumi Y. Autophagy, 2012, 8, 177-186.

• Atg4 proteases in autophagy. Nakatogawa H, Ohsumi Y. Handbook of Proteolytic Enzymes, 3rd Edn., 2012, 2138-2142.
• SDS-PAGE techniques to study ubiquitin-like conjugation systems in yeast autophagy. Nakatogawa H, Ohsumi Y. Methods Mol. Biol., 2012, 832, 519-529.

2011

• Structural basis of Atg8 activation by a homodimeric E1, Atg7. Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y, Inagaki F. Mol. Cell, 2011, 44, 462-475.
• Selective autophagy regulates insertional mutagenesis by the Ty1 retrotransposon in Saccharomyces cerevisiae. Suzuki K, Morimoto M, Kondo C, Ohsumi Y. Dev. Cell, 2011, 21, 358-365.
• Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction. Suzuki SW, Onodera J, Ohsumi Y. PLoS ONE, 2011, 6, e17412.

• The role of Atg proteins in autophagosome formation. Mizushima N, Yoshimori T, Ohsumi Y. Annu. Rev. Cell Dev. Biol., 2011, 27, 107-132.
• Atg14, a key player in orchestrating autophagy. Obara K, Ohsumi Y. Int. J. Cell Biol., 2011, 2011, 713435.
• PtdIns 3-kinase orchestrates autophagosome formation in yeast. Obara K, Ohsumi Y. J. Lipids, 2011, 2011, 498768.

2010

• Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by ATG19 and ATG34. Watanabe Y, Noda NN, Kumeta H, Suzuki K, Ohsumi Y, Inagaki F. J. Biol. Chem, 2010, 285, 30026-30033.
• Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, ATG34. Suzuki K, Kondo C, Morimoto M, Ohsumi Y. J. Biol. Chem, 2010, 285, 30019-30025.
• Autophagy-related protein (Atg) 8-family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway. Yamaguchi M, Noda NN, Nakatogawa H, Kumeta H, Ohsumi Y, Inagaki F. J. Biol. Chem, 2010, 285, 29599-29607.
• The NMR structure of the autophagy-related protein Atg8. Kumeta H, Watanabe M, Nakatogawa H, Yamaguchi M, Ogura K, Adachi W, Fujioka Y, Noda NN, Ohsumi Y, Inagaki F. J. Biomol. NMR, 2010, 47, 237-241.
• Tor directly controls the Atg1 kinase complex to regulate autophagy. Kamada Y, Yoshino K, Kondo C, Kawamata T, Oshiro N, Yonezawa K, Ohsumi Y. Mol. Cell Biol., 2010, 30, 1049-1058.
• The dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy. Fujioka Y, Noda NN, Nakatogawa H, Ohsumi Y, Inagaki F. J. Biol. Chem., 2010, 285, 1508-1515.

• The TOR-mediated regulation of autophagy in the yeast, Saccharomyces cerevisiae. Kamada Y, Ohsumi Y. The Enzymes, 2010, 28, 143-165.
• Current knowledge of the pre-autophagosomal structure (PAS). Suzuki K, Ohsumi Y. FEBS lett., 2010, 584, 1280-1286.
• Atg8-family interacting motif crucial for selective autophagy. Noda NN, Ohsumi Y, Inagaki F. FEBS lett., 2010, 584, 1379-1385.

2009

• Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Yoshimoto K, Jikumaru Y, Kamiya Y, Kusano M, Consonni C, Panstruga R, Ohsumi Y, Shirasu K. Plant Cell, 2009, 21, 2914-2927.
• Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Kabeya Y, Noda NN, Fujioka Y, Suzuki K, Inagaki F, Ohsumi Y. Biochem. Biophys. Res. Comm, 2009, 389, 612-615.
• Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Okamoto K, Kondo-Okamoto N, Ohsumi Y. Dev. Cell, 2009, 17, 87-97.
• Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway. Watanabe Y, Noda NN, Honbou K, Suzuki K, Sakai Y, Ohsumi Y, Inagaki F. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 2009, 65, 571-573.
• The structure of Atg4B-LC3 complex reveals the mechanism of LC3-processing and delipidation during autophagy. Satoo K, Noda NN, Kumeta H, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F. EMBO J., 2009, 28, 1341-1350.
• The amino-terminal region of Atg3 is essential for association with phosphatidylethanolamine in Atg8 lipidation. Hanada T, Satomi Y, Takao T, Ohsumi Y. FEBS Lett., 2009, 583, 1078-1083.
• OsATG10b, an autophagosome component, is needed for cell survival against oxidative stresses in rice. Shin JH, Yoshimoto K, Ohsumi Y, Jeon JS, An G. Mol Cells., 2009, 27, 67-74.
• Atg17 recruits Atg9 to organize the pre-autophagosomal structure. Sekito T, Kawamata T, Ichikawa R, Suzuki K, Ohsumi Y. Genes Cells, 2009, 14, 525-538.
• Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae. Kageyama T, Suzuki K, Ohsumi Y. Biochem. Biophys. Res. Comm., 2009, 378, 551-557.
• Autophagy plays a role in chloroplast degradation during senescence in individually darkened leaves. Wada S, Ishida H, Izumi M, Yoshimoto K, Ohsumi Y, Mae T, Makino A. Plant Physiol., 2009, 149, 885-893.

• A landmark protein essential for mitophagy. Okamoto K, Kondo-Okamoto N, Ohsumi Y. Autophagy, 2009, 5, 1203-1206.
• Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y. Nat. Rev. Mol. Cell Biol., 2009, 10, 458-467.
• ATG Systems from the Protein Structural Point of View. Noda NN, Ohsumi Y, Inagaki F. Chem Rev., 2009, 109, 1587-1598.

2008

• Structural basis of target recognition by Atg8/LC3 during selective autophagy. Noda NN, Kumeta H, Nakatogawa H, Satoo K, Adachi W, Ishii J, Fujioka Y, Ohsumi Y, Inagaki F. Genes Cells, 13, 1211-1218.
• Crystallization of the coiled-coil domain of Atg16 essential for autophagy. Fujioka Y, Noda NN, Matsushita M, Ohsumi Y, Inagaki F. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 2008, 64, 1046-1048.
• Mobilization of Rubisco and stromal-localized fluorescent proteins of chloroplasts to the vacuole by an ATG gene-dependent autophagic process. Ishida H, Yoshimoto K, Izumi M, Reisen D, Yano Y, Makino A, Ohsumi Y, Hanson MR, Mae T. Plant Physiol., 2008, 148, 142-155.
• The Atg18-Atg2 complex is recruited to autophagic membranes via PtdIns(3)P and exerts an essential function. Obara K, Sekito T, Niimi K, Ohsumi Y. J. Biol. Chem., 2008, 283, 23972-23980.
• Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8. Oh-oka K, Nakatogawa H, Ohsumi, Y. J. Biol. Chem., 2008, 283, 21847-21852.
• The yeast Tor signaling pathway is involved in G2/M transition via Polo-kinase. Nakashima A, Maruki Y, Imamura Y, Kondo C, Kawamata T, Kawanishi I, Takata H, Matsuura A, Lee KS, Kikkawa U, Ohsumi Y, Yonezawa K, Kamada Y. PLoS ONE, 2008, 3, e2223.
• Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in S. cerevisiae. Obara K, Noda T, Niimi K, Ohsumi Y. Genes Cells, 2008, 13, 537-547.
• Organization of the pre-autophagosomal structure responsible for autophagosome formation. Kawamata T, Kamada Y, Kabeya Y, Sekito T, Ohsumi Y. Mol. Biol. Cell, 2008, 19, 2039-2050.
• Crystallization of the Atg12-Atg5 conjugate bound to Atg16 by the free-interface diffusion method. Noda NN, Fujioka Y, Ohsumi Y, Inagaki F. J. Synchrotron Radiat., 2008, 15, 266-268.
• PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans. Hu G, Hacham M, Waterman SR, Panepinto J, Shin S, Liu X, Gibbons J, Valyi-Nagy T, Obara K, Jaffe HA, Ohsumi Y, Williamson PR. J. Clin. Invest., 2008, 118, 1186-1197.
• In vitro reconstitution of plant ATG8 and ATG12 conjugation systems essential for autophagy. Fujioka Y, Noda NN, Fujii K, Yoshimoto K, Ohsumi Y, Inagaki F. J. Biol. Chem., 2008, 283, 1921-1928.

• Dynamics and function of PtdIns(3)P in autophagy. Obara K, Ohsumi Y. Autophagy, 2008, 4, 952-954.
• Lipidation of Atg8: How is substrate specificity determined without a canonical E3 enzyme? Nakatogawa H, Oh-oka K, Ohsumi Y. Autophagy, 2008, 4, 911-913.
• Novel families of vacuolar amino acid transporters. Sekito T, Fujiki Y, Ohsumi Y, Kakinuma Y. IUBMB Life, 2008, 60, 519-525.
• Starved cells eat ribosomes. Nakatogawa H, Ohsumi Y. Nat. Cell Biol., 2008, 10, 505-507.

2007

• The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y. J. Biol. Chem., 2007, 282, 37298-37302.
• Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Nakatogawa H, Ichimura Y, Ohsumi Y. Cell, 2007, 130, 165-178.
• Crystallization and preliminary X-ray analysis of Atg10. Yamaguti M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F. Acta Crystallograph Sect F Struct Biol Cryst Commun., 2007, 63, 443-445.
• Cis1/Atg31 is requir ed for autophagosome formation in Saccharomyces cerevisiae. Kabeya Y, Kawamata T, Suzuki K, Ohsumi Y. Biochem. Biophys. Res. Comm., 2007, 356, 405-410.
• An Arabidopsis homolog of Yeast ATG6/VPS30 is essential for pollen germination. Fujiki Y, Yoshimoto K, Ohsumi Y. Plant Physiology, 2007, 143, 1132-1139.
• The crystal structure of ATG3, an autophagy-related E2 enzyme that mediates ATG8 lipidation. Yamada Y, Suzuki NN, Hanada T, Ichimura Y, Kumeta H, Fujioka Y, Ohsumi Y, Inagaki F. J Biol Chem., 2007, 282, 8036-8043.
• Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway. Adachi W, Suzuki NN, Fujioka Y, Suzuki K, Ohsumi Y, Inagaki F. Acta Crystallograph Sect F Struct Biol Cryst Commun., 2007, 63, 200-203.
• Crystallization and preliminary crystallographic analysis of human Atg4B-LC3 complex. Satoo K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F. Acta Crystallograph Sect F Struct Biol Cryst Commun., 2007, 63, 99-102.
• Structure of ATG5*ATG16, a complex essential for autophagy. Matsushita M, Suzuki NN, Obara K, Fujioka Y, Ohsumi Y, Inagaki F. J Biol Chem., 2007, 282, 6763-6772.
• Hierarchy of Atg proteins in pre-autophagsomal structure organization. Suzuki K, Kubota Y, Sekito T, Ohsumi Y. Genes Cells, 2007,12, 209-218.

• Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. Suzuki K, Ohsumi Y. FEBS Lett., 2007, 581, 2156-2161.

2006

• AtATG genes, homologs of yeast autophagy genes, are involved in constitutive autophagy in Arabidopsis root tip cells. Inoue Y, Suzuki T, Hattori M, Yoshimoto K, Ohsumi Y, Moriyasu Y. Plant Cell Physiol., 2006, 47,1641-1652.
• Expression, purification and crystallization of the Atg5-Atg16 complex essential for autophagy. Matsushita M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun., 2006, 62, 1021-1023.
• Crystallization and preliminary X-ray analysis of Atg3. Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun., 2006, 62, 1016-1017.
• Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy. Amar N, Lustig G, Ichimura Y, Ohsumi Y, Elazar Z. EMBO Rep., 2006, 7, 635-642.
• Assortment of phosphatidylinositol 3-kinase complexes - Atg14p directs association of complex I to the pre-autophagosomal structure in S. cerevisiae -. Obara K, Sekito T, Ohsumi Y. Mol. Biol. Cell, 2006, 17, 1527-1539.
• Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Matsui M, Yamamoto A, Kuma A, Ohsumi Y, Mizushima N. Biochem. Biophys. Res. Comm., 2006 Jan 13;339(2):485-489.

• Protein turnover. Ohsumi Y. IUBMB Life, 2006, 58 (5-6): 363-369.
• Autophagy in development and stress responses of plants. Bassham DC, Laporte M., Marty F, Moriyasu Y, Ohsumi Y, Olsen LJ, Yoshimoto K. Autophagy, 2006, 2 (1): 2-11.

2005

• Characterization of a novel autophagy-specific gene, ATG29. Kawamata T, Kamada, Y, Suzuki K, Kuboshima N, Akimatsu H, Oota S, Ohsumi M, Ohsumi Y. Biochem. Biophys. Res. Comm., 2005, 338, 1884-1889.
• Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F. J. Biol. Chem., 2005 Dec 2;280(48):40058-65.
• Autophagy is required for maintenance of amino acids levels and protein synthesis under nitrogen starvation. Onodera J, Ohsumi Y. J. Biol. Chem., 2005 Sep;9(280):31582-31586.
• Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y. Mol. Cell. Biol., 2005 Aug;25(16):7239-7248.
• Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Ohsumi Y, Jung YK. J. Biol. Chem., 2005 May 27;280(21):20722-9.
• Structure-Function Relationship of Atg12, a Ubiquitin-Like Modifier Essential for Autophagy Hanada T, Ohsumi Y. Autophagy, July/August/September; 1(2):110-118.
• The Crystal Structure of Plant ATG12 and its Biological Implication in Autophagy Suzuki NN, Yoshimoto K, Fujioka Y, Ohsumi Y, Inagaki F. Autophagy, July/August/September; 1(2):119-126.
• Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. J. Cell Biol., 2005 May 9;169(3):425-34.
• Atg17 Functions in Cooperation with Atg1 and Atg13 in Yeast Autophagy. Kabeya Y, Kamada Y, Baba M, Takikawa H, Sasaki M, Ohsumi Y. Mol. Biol. Cell, 2005 May,16, 2544-2553.
• Starvation Triggers the Delivery of the Endoplasmic Reticulum to the Vacuole via Autophagy in Yeast. Hamasaki M, Noda T, Baba M, Ohsumi Y. Traffic, 2005 Jan;6(1):56-65.
• A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. Shimazu M, Sekito T, Akiyama K, Ohsumi Y, Kakinuma Y. J Biol Chem., 2005 Feb 11;280(6):4851-7.
• A Sorting Nexin PpAtg24 Regulates Vacuolar Membrane Dynamics during Pexophagy via Binding to Phosphatidylinositol-3-Phosphate. Ano Y, Hattori T, Oku M, Mukaiyama H, Baba M, Ohsumi Y, Kato N, Sakai Y. Mol Biol Cell, 2005 Feb;16(2):446-57.

2004

• The role of autophagy during the early neonatal starvation period. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. Nature, 2004 Dec 23;432(7020):1032-6.
• Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Yoshimoto K, Hanaoka H, Sato S, Kato T, Tabata S, Noda T, Ohsumi Y. Plant Cell, 2004 Nov;16(11):2967-83.
• Interrelationships among Atg proteins during autophagy in Saccharomyces cerevisiae. Suzuki K, Noda T, Ohsumi Y. Yeast, 2004 Sep 27;21(12):1057-65.
• In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. Ichimura Y, Imamura Y, Emoto K, Umeda M, Noda T, Ohsumi Y. J. Biol. Chem., 2004 Sep 24;279(39):40584-92.
• The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F. Genes Cells, 2004 Jul;9(7):611-8.
• apg15-1, a UGA mutant allele in the Saccharomyces cerevisiae APG16 gene, and its suppression by a cytoplasmic factor. Okazaki H, Ono B, Ohsumi Y, Ohsumi M. Biosci Biotechnol Biochem., 2004 Jul;68(7):1541-8.
• Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast. Ichimura T, Kubota H, Goma T, Mizushima N, Ohsumi Y, Iwago M, Kakiuchi K, Shekhar HU, Shinkawa T, Taoka M, Ito T, Isobe T. Biochemistry, 2004 May 25;43(20):6149-58.
• LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation Kabeya Y, Mizushima N,Yamamoto A, Oshitani-Okamoto S, Ohsumi Y,Yoshimori T J. Cell Sci., 2004 Jun 1;117(13):2805-12.
• Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae Onodera J, Ohsumi Y J. Biol. Chem., 2004 Apr 16;279(16):16071-6.
• In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y Mol. Biol. Cell, 2004 Mar;15(3):1101-11.
• Modification of a ubiquitin-like protein Paz2 conducted micropexophagy through formation of a novel membrane structure Mukaiyama H, Baba M, Osumi M, Aoyagi S, Kato N, Ohsumi Y, Sakai Y Mol. Biol. Cell, 2004 Jan;15(1):58-70.

• Cellular recycling system- molecular mechanism of autophagy. Ohsumi Y. In Cell Growth, Cold Spring Harbor Press, 2004 ipp412-429
• Two ubiquitin-like conjugation systems essential for autophagy. Ohsumi Y, Mizuhsima N. Semin. Cell Dev. Biol., 2004 Apr;15(2):231-6.
• Autophagy in yeast: a TOR-mediated response to nutrient starvation. Kamada Y, Sekito T, Ohsumi Y Curr. Top. Microbiol. Immunol., 2004;279:73-84

2003

• Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G, Levine B J. Clin. Invest., 2003 Dec;112(12):1809-20.
• A unified nomenclature for yeast autophagy-related genes Klionsky DJ, Cregg JM, Dunn WA Jr, Emr SD, Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M, Ohsumi Y Dev. Cell., 2003 Oct;5(4):539-45.
• Crystallization and preliminary X-ray analysis of LC3-I Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F Acta. Crystallogr. D Biol. Crystallogr., 2003 Aug;59(Pt 8):1464-5.
• Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate Mizushima N, Kuma A, Kobayashi Y, Yamamoto A, Matsubae M, Takao T, Natsume T, Ohsumi Y, Yoshimori T. J. Cell. Sci., 2003 May 1;116(Pt 9):1679-88.
• The early secretory pathway contributes to autophagy in yeast Hamasaki M, Noda T, Ohsumi Y. Cell Struct. Funct., 2003 Feb;28(1):49-54.

• Role of the Apg12 conjugation system in mammalian autophagy Mizushima N, Yoshimori T, Ohsumi Y. Int. J. Biochem. Cell Biol., 2003 May;35(5):553-61.
• The pre-autophagosomal structure (PAS), required for the formation of autophagosome membrane Suzuki K, Ohsumi Y. Seikagaku., 2003 Jun;75(6):492-9. Japanese. No abstract available.

2002

• Mouse Apg10 as an Apg12 conjugating enzyme: Analysis by the conjugation-mediated yeast two-hybrid method Mizushima N, Yoshimori T, Ohsumi Y. FEBS Lett., 2002 Dec 18:450-454.
• Autophagosome formation in Mammalian cells Mizushima N, Ohsumi Y, Yoshimori T Cell Struct Funct., 2002 Dec;27(6):421-9.
• Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae Suzuki K, Kamada Y, Ohsumi Y. DevCell, 2002 Dec;(3):815-824.
• Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene Hanaoka H, Noda T, Shirano Y, Kato T, Hayashi H, Shibata D, Tabata S, Ohsumi Y. Plant Physiol., 2002 Jul;129(3):1181-93.
• The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy Suzuki T, Nakagawa M, Yoshikawa A, Sasagawa N, Yoshimori T, Ohsumi Y, Nishino I, Ishiura S, Nonaka I. J Biochem (Tokyo)., 2002 May;131(5):647-51.
• Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast Kuma A, Mizushima N, Ishihara N, Ohsumi Y. J Biol Chem., 2002 May 24;277(21):18619-25.
• SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation Nara A, Mizushima N, Yamamoto A, Kabeya Y, Ohsumi Y, Yoshimori T. Cell Struct Funct., 2002 Feb;27(1):29-37.

• Yeast autophagosomes: de novo formation of a membrane structure Noda T, Suzuki K, Ohsumi Y. Trends Cell Biol., May;12(5):231-5, 2002

2001

• The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T. and Ohsumi, Y. EMBO J., 20, 5971-5981 (2001)
• Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for its fusion to the vacuole. Ishihara, T., Hamasaki, M., Yokota, S., Suzuki, K., Kamada, Y., Kihara, A., Yoshimori, T., Noda, T., and Ohsumi, Y. Mol. Biol. Cell, 12, 3690-3702 (2001)
• Apg2p functions in autophagosome formation on the perivacuolar structure. Shintani T, Suzuki K, Kamada Y, Noda T, Ohsumi Y. J. Biol Chem., 276, 30452-30460 (2001)
• Dissection of Autophagosome Formation using Apg5-deficient Mouse Embryonic Stem Cells Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y.,Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y. and Yoshimori, T. J. Cell Biol., 152, 657-667 (2001)
• Two distinct Vps34 PtdIns 3-kinase Complexes functionin autophagy and CPY sorting in Saccharomyces cevisiae Kihara, A., Noda, T., Ishihara, N. and Ohsumi, Y. J. Cell Biol., 152, 519-530 (2001)
• The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1-activity and E1-E2 complex-formation Komatsu,M., Tanida, I., Ueno, T., Ohsumi, M., Ohsumi, Y., and Kominami, E. J. Biol. Chem., 276, 9846-9854 (2001)
• Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole Kim, J., Kamada, Y., Stromhaug, P.E. Guan, J.,Hefner-Gravinnk, A., Bevan,A., Scott, S. V. Ohsumi, Y., Dunn, Jr., W. A., Klionsky, D.J. J. Cell. Biol., 153, 381-396 (2001)
• Beclin-Phsophatidylinositol 3-kinase complex functions at the trans-Golgi Network Kihara, A., Kabeya, Y., Ohsumi, Y., and Yoshimori T. EMBOReport, 2, 330-335 (2001)

• Molecular dissection of autophagy: two ubiquitin-like systems Y. Ohsumi Nat. Rev. Mol. Cell Biol., 2, 211-216, 2001

2000

• A ubiquitin-like system mediates protein lipidation Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., Noda, T. and Ohsummi, Y. Nature, 408, 488-492 (2000)
• Reversible modification regulares the memrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N.,Yoshimori, T., Ohsumi, M., Noda, T. and Ohsumi, Y. J. Cell Biol., 151, 263-276 (2000)
• Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion Grote, E, Baba M., Ohsumi, Y., Novick, P.J. J. Cell. Biol., 151, 453-466 (2000)
• LC3, a mammalian homologue of yeast apg8p is processed and localized in autophagosome membranes Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., and Yoshimori, T. EMBO. J., 19, 5720-5728 (2000)
• Tor-mediated induction of autophgay via an Apg1 protein kinase complex Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., Ohsumi, Y J. Cell Biol., 150, 1507-1513 (2000)
• Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting Scott, S. V., Nice III, D. C., Nau, J.J. Weisman, L.S., Kamada, Y., Keizer-Gunnink, I., Funakoshi, T., Veenhuis, M., Ohsumi,Y., Klionsky, D. J. J. Biol. Chem., 275, 25840-25849 (2000)
• A Protein Conjugation System in Yeast with Homology to Biosynthetic Enzyme Reaction of Prokaryotes Furukawa K, Mizushima N, Noda T, Ohsumi Y J. Biol. Chem., 000 Mar17; 275 ( 11), 7462-7465
• Apg5p Functions in the Sequestration Step in the Cytoplasm-to-Vacuole Targeting and Macroautophagy Pathways George MD, Baba M, Scott SV, Mizushima N, Garrison BS, Ohsumi Y, Klionsky DJ Mol. Biol. Cell, 2000 Mar;11(3):969-982
• The Mouse SKD1, a Homologue of Yeast Vps4p, Is Required for Normal Endosomal Trafficking and Morphology in Mammalian Cells Yoshimori T, Yamagata F, Yamamoto A, Mizushima N, Kabeya Y, Nara A, Miwako I, Ohashi M, Ohsumi M, Ohsumi Y, Mol. Biol. Cell, 2000 Feb;11(2):747-763
• Apg9p/Cvt7p Is an Integral Membrane Protein Required for Transport Vesicle Formation in the Cvt and Autophagy Pathways Noda T, Kim J, Huang WP, Baba M, Tokunaga C, Ohsumi Y, and Klionsky DJ, J. Cell Biol., 2000 Feb 7;148(3): 465-480

• The yeast vacuole: A paradigm for Plant cell Biologist Noda, T., Y. Ohsumi and D. Klionsky Annual Plant Reviews, 5: 1-191, 2000

1999

• Patch clamp studies on V-type ATPase of vacuolar membrane of haploid saccharomyces cerevisiae. Preparation and utilization of a giant cell containing a giant vacuole Yabe I, Horiuchi Ki, Nakahara K, Hiyama T, Yamanaka T, Wang PC, Toda K, Hirata A, Ohsumi Y, Hirata R, Anraku Y, Kusaka I J. Biol. Chem., 1999 Dec 3;274(49):34903-10
• Formation process of autophagosome is traced with Apg8/Aut7p in yeast. Kirisako T, Baba M, Ishihara N, Miyazawa K, Ohsumi M, Yoshimori T, Noda T, Ohsumi Y J. Cell Biol., 1999 Oct 18;147(2):435-46
• Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. Shintani T, Mizushima N, Ogawa Y, Matsuura A, Noda T, Ohsumi Y EMBO J., 1999 Oct 1;18(19):5234-41
• Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. Mizushima N, Noda T, Ohsumi Y EMBO J., 1999 Jul 15;18(14):3888-96
• Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Tanida I, Mizushima N, Kiyooka M, Ohsumi M, Ueno T, Ohsumi Y, Kominami E Mol. Biol. Cell, 1999 May;10(5):1367-79

• Vacuolar import of proteins and organelles from the cytoplasm Klionsky DJ, Ohsumi Y Annu. Rev. Cell Dev. Biol., 1999. 15:1-32

1998

• A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. Mizushima N, Sugita H, Yoshimori T, Ohsumi Y J. Biol. Chem., 1998 Dec 18;273(51):33889-92
• A protein conjugation system essential for autophagy. Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, Klionsky DJ, Ohsumi M, Ohsumi Y Nature, 1998 Sep 24;395(6700):395-8
• Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. Kametaka S, Okano T, Ohsumi M, Ohsumi Y J. Biol. Chem., 1998 Aug 28;273(35):22284-91
• Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. Noda T, Ohsumi Y J. Biol. Chem., 1998 Feb 13;273(7):3963-6

1997

• Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome. Baba M, Osumi M, Scott SV, Klionsky DJ, Ohsumi Y J. Cell Biol., 1997 Dec 29;139(7):1687-95
• Mutational analysis of Csc1/Vps4p: involvement of endosome in regulation of autophagy in yeast. Shirahama K, Noda T, Ohsumi Y Cell Struct. Funct., 1997 Oct;22(5):501-9
• The AtVAM3 encodes a syntaxin-related molecule implicated in the vacuolar assembly in Arabidopsis thaliana. Sato MH, Nakamura N, Ohsumi Y, Kouchi H, Kondo M, Hara-Nishimura I, Nishimura M, Wada Y J. Biol. Chem., 1997 Sep 26;272(39):24530-5
• Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism. Scott SV, Baba M, Ohsumi Y, Klionsky DJ J. Cell Biol., 1997 Jul 14;138(1):37-44
• Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Matsuura A, Tsukada M, Wada Y, Ohsumi Y Gene, 1997 Jun 19;192(2):245-50
• Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. Funakoshi T, Matsuura A, Noda T, Ohsumi Y Gene, 1997 Jun 19;192(2):207-13
• Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae. Wada Y, Nakamura N, Ohsumi Y, Hirata A J. Cell Sci., 1997 Jun;110 ( Pt 11):1299-306
• Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. Nakamura N, Hirata A, Ohsumi Y, Wada Y J. Biol. Chem., 1997 Apr 25;272(17):11344-9
• Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiae. Nakamura N, Matsuura A, Wada Y, Ohsumi Y J. Biochem. (Tokyo), 1997 Feb;121(2):338-44

- 1996

• Vacuolar function in the phosphate homeostasis of the yeast Saccharomyces cerevisiae. Shirahama K, Yazaki Y, Sakano K, Wada Y, Ohsumi Y. Plant Cell Physiol., 1996 Dec;37(8):1090-3.
• Structural and functional analyses of APG5, a gene involved in autophagy in yeast. Kametaka S, Matsuura A, Wada Y, Ohsumi Y. Gene., 1996 Oct 31;178(1-2):139-43.
• Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole. Scott SV, Hefner-Gravink A, Morano KA, Noda T, Ohsumi Y, Klionsky DJ. Proc. Natl. Acad. Sci. USA., 1996 Oct 29;93(22):12304-8.
• Autophagy in Tobacco Suspension-Cultured Cells in Response to Sucrose Starvation. Moriyasu Y, Ohsumi Y. Plant Physiol, 1996 Aug;111(4):1233-1241.
• Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method. Baba M, Osumi M, Ohsumi Y. Cell Struct Funct., 1995 Dec;20(6):465-71.
• Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Noda T, Matsuura A, Wada Y, Ohsumi Y. Biochem Biophys Res Commun., 1995 May 5;210(1):126-32.
• Saccharomyces cerevisiae MATa mutant cells defective in pointed projection formation in response to alpha-factor at high concentrations. Yorihuzi T, Ohsumi Y Yeast, 1994 May;10(5):579-94
• Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization. Baba M, Takeshige K, Baba N, Ohsumi Y. J. Cell Biol., 1994 Mar;124(6):903-13.
• Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. Tsukada M, Ohsumi Y FEBS Lett., 1993 Oct 25;333(1-2):169-74.
• Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. Takeshige K, Baba M, Tsuboi S, Noda T, Ohsumi Y. J. Cell Biol., 1992 Oct;119(2):301-11